A memory is a stored pattern of connections between neurons in the brain. There are about 100 billion of those neurons, each of which can make perhaps 5,000 to 10,000 synaptic connections with other neurons, which makes a total of about 500 trillion to a 1000 trillion synapses in the average adult brain. Every sensation we remember, every thought we think, alters the connections within that vast network. Synapses are strengthened or weakened or formed anew. Our physical substance changes. Indeed, it is always changing, every moment, even as we sleep. – Joshua Foer
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